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KMID : 0882420070730030243
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Korean Journal of Medicine
2007 Volume.73 No. 3 p.243 ~ p.250
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Antiretroviral drug resistance among drug-naive HIV-1 infected patients
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Kim Seo-Rin
Rheu Eun-Kyung
Sol Young-Mi
Cha Dong-Hyuk
Lee Su-Jin
Yoon Yeon-Kyung
Park Soon-Mi
Kim Hyung-Hoi
Rheu Hak-Sun
Ahn Soon-Cheol
Lee Sun-Hee
Kwak Ihm-Soo
Cho Goon-Jae
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Abstract
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Background : The prevalence of HIV drug resistance mutations in drug-naive patients has been shown to differ with geographic origin. The purpose of this study is to assess the prevalence of transmitted antiretroviral drug resistance
mutations in drug-naive patients in Korea.
Methods : Genotypic resistance was determined by the use of the Viroseq Genotyping System in 42 antiretroviral
treatment naive HIV-infected patients between March 2005 and July 2006. Transmitted drug resistance was estimated
according to the IAS-USA 2005 definition, taking into account only major mutations in the protease and all mutations
in the reverse transcriptase, including revertant mutations at codon 215.
Results : The median age of the patients was 42 years and 37 (88%) were male. The median CD4+T cell count was 136/mm3 and the mean plasma RNA level was 4.98 log copies/mL. Among 42 patients studied, 37 (88%) were newly
diagnosed patients. None of the patients were recent seroconverters; 38 patients (90%) were infected with subtype B and
4 patients were infected (10%) with the non-B subtype strains (2 patients with CRF01-AE 1 as CRF02-AG; 1 patient
with subtype A). Of the 42 subjects tested, we found 2 (4.8%) mutations in NRTI (V118I), but did not find a mutation
in NNRTI as well as in the PI region.
Conclusion : The prevalence of transmitted antiretroviral drug resistance in drug-naive patients is still low in
Korean patients.(Korean J Med 73:243-250, 2007)
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KEYWORD
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HIV, Antiretroviral agent, Drug resistance
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